t(12;17)(p13;q12)/TAF15-ZNF384 Rearrangement in Acute Lymphoblastic Leukemia
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منابع مشابه
t(12;17)(p13;q12)/TAF15-ZNF384 Rearrangement in Acute Lymphoblastic Leukemia
Dear Editor, In ALL, cytogenetic subgroups according to recurrent genetic abnormalities are used to classify patients for risk stratification and to introduce them to the proper therapeutic strategies— such as the use of tyrosine kinase inhibitors in the case of t(9;22)(q34;q11.2)/BCR-ABL1 fusion [1]. Therefore, the identification of genetic aberrations is clinically significant and crucial in ...
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The bcr-abl rearrangement in T-lineage ALL has been rarely described. In the last three years we studied all new patients with ALL at diagnosis by cytogenetic and molecular analysis. Three out of eleven T-lineage ALL patients presented the rearrangement and only one was Philadelphia positive.
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Leukemia is the most common childhood cancer and accounts for 30-40% of all malignancies. A retrospective review was performed of the hospital records of 9 children, 6 boys and 3 girls, aged from 2.5 to 15 years with ALL initially referred to Nemazee hospital Nuclear medicine center for whole body bone scanning between 2000 and 2002. Bone marrow pathology established ALL (L1) in two and ALL (...
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Ubiquitin - proteasome system (UPS), the major protein degradation pathway in the cells, typically degrades short - lived and damaged proteins and regulates growth and stress responses. This pathway is altered in various cancers, including Acute Lymphoblastic Leukemia (ALL). ALL begins with a change in bone marrow cells and is the most common type of leukemia in children under 15 years. UBE2Q1...
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ژورنال
عنوان ژورنال: Annals of Laboratory Medicine
سال: 2016
ISSN: 2234-3806,2234-3814
DOI: 10.3343/alm.2016.36.4.396